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Antioxidants

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By: Sean Moloughney

Editor, Nutraceuticals World

Indication: Age-related macular degeneration (AMD)

Source: JAMA December, 2005;294(24):3101-7.

Research: The purpose of the study was to investigate whether regular dietary intake of antioxidants is associated with a lower risk of incident AMD. Researchers used data collected from the Rotterdam Study (1990-1993) using a semiquantitative food frequency questionnaire. Incident AMD until final follow-up in 2004 was determined by grading fundus color transparencies in a masked way according to the International Classification and Grading System. The subjects in the study came from a middle-class suburb of Rotterdam, the Netherlands. They were 55 years of age or older. Of 5836 persons at risk of AMD at baseline, 4765 had reliable dietary data and 4170 participated in the follow-up.

Results: Incident AMD occurred in 560 participants after a mean follow-up of eight years. Dietary intake of both vitamin E and zinc was inversely associated with incident AMD. An above-median intake of all four nutrients, beta-carotene, vitamin C, vitamin E and zinc, was associated with a 35% reduced risk of AMD. Exclusion of supplement users did not affect the results.

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